The desmoplastic ameloblastoma da is a rare variant of the conventional ameloblastoma. Four years later, the lesion recurred, and was diagnosed as a desmoplastic. It usually presents as a painless enlargement of the jaw. Case of desmoplastic ameloblastoma arising in the anterior. Ameloblastoma, peripheral, desmoplastic, immunohistochemistry.
A case of desmoplastic ameloblastoma occupying maxillary. So, desmoplastic ameloblastoma should be simply noted for its distinctive radiographic. Clinical and radiologic behaviour of ameloblastoma in 4 cases. Up to 1992, the world health organization oms recognized the existence of 3 distinctive clinicopathologic variants of ameloblastoma, called conventional solid ameloblastoma, unicystic ameloblastoma and peripheral ameloblastoma3. Establishing the natural history and growth rate of ameloblastoma. The authors present a rare case of desmoplastic ameloblastoma da involving the jaw. Ameloblastoma is a benign neoplasm essentially composed of epithelial tissue that has an invasive and infiltrative behavior at. A detailed report was given in 1984 by eversole and his coworkers on this variant of ameloblastoma. Desmoplastic ameloblastoma is rare, accounting for approximately 4% to % of ameloblastomas. Desmoplastic ameloblastoma a report of two clinical cases. Ameloblastoma ab is the second most common benign epithelial odontogenic tumor.
In this type, the islands of ameloblastoma are surrounded and often compressed by a dense and sometimes hyalinised fibrous connective tissue. We report a case of desmoplastic ameloblastoma in a 45yearold female with a painless swelling in. We report a rare case of desmoplastic ameloblastoma lesion that filled the entire maxillary sinus. Nov 24, 2006 follicular ameloblastoma was the most common histological type 50 cases, 64.
Although the majority of the tumours originate from. Histopathologically classified as follicular, acanthomatous, granular, basal, desmoplastic and plexiform ameloblastoma. Owing to its deceptive radiological appearance as a mixed radiopaqueradiolucent lesion. Pathology of the desmoplastic ameloblastoma kishino. The biologic profile of this tumor is not fully understood because of the limited number of reported cases. Desmoplastic ameloblastoma da is relatively rare histologic variant of. Recurrent desmoplastic ameloblastoma of the maxilla no typical radiographic features are associated with this variant of ameloblastoma, although a mixed radiolucent radiopaque appearance with illde. In the world health organization classification of odontogenic tumors 2005, desmoplastic ameloblastoma. Here we report a case of plexiform ameloblastoma of the left maxilla in a 30yearold male. Plexiform ameloblastoma does not have prominent palisading. Desmoplastic ameloblastoma da is one of the 6 histopathological subtypes of ameloblastoma. This tumor is more commonly seen in the anterior region of jaws as a mixed radiopaqueradiolucent lesion resembling benign fibroosseous lesions. A wide variety of odontogenic cysts and tumors may arise from these diverse cellular elements.
Ameloblastoma has no established preventive measures although majority of patients are between ages 30 and 60 years. A case report on desmoplastic ameloblastoma of anterior. Desmoplastic ameloblastoma da is an epithelial odontogenic tumor, a rare variant of ameloblastoma. Desmoplastic ameloblastoma da is a rare variant that accounts for approximately 4 % of ameloblastoma, displaying significant differences in anatomical site, imaging, and histologic appearance. Desmoplastic ameloblastoma da is an unusual type of. Ameloblastoma arising from a dentigerous cysta case. Clinicopathological analysis of histological variants of. A panoramic radiograph showed an area of radiolucency with a welldefined. The condition most often occurs in adults in their 30s and 40s, though it can occur at any age. Desmoplastic ameloblastoma da is a rare variant of ameloblastoma, and less than patients have been reported in the literature.
Functional imaging combining petct is particularly useful for diagnosing. Review of literature with a case report vindhya savithri, mahija janardhanan, rakesh suresh, rb vinod kumar department of oral pathology and microbiology, amrita school of dentistry, kochi, india case report address for correspondence. It is defined as a variant of ameloblastoma with specific imaging and histological features. Tumors of odontogenic origin may arise from the epithelial cells, the ectomesenchymal component, or a combination of both cell lines. This blend of different clinicopathologic ameloblastomas was. A repeatedly recurrent desmoplastic ameloblastoma after. Case report desmoplastic ameloblastoma a report of two clinical cases article pdf available in brazilian journal of oral sciences 92. A panoramic xray captured an image of a mixture of illdefined radiolucency and radiopacity from the swollen area to the maxillary sinus. A desmoplastic ameloblastoma with features of other histologic types is considered to be a hybrid lesion. Desmoplastic ameloblastoma da is a rare variant that accounts for approximately 4 % of ameloblastoma, displaying significant differences in anatomical site. Desmoplastic ameloblastoma is a rare variant of ameloblastoma.
Ameloblastoma nord national organization for rare disorders. Desmoplastic ameloblastoma da is relatively rare histologic variant of solid multicystic ameloblastoma sma which is characterized by its peculiar histomorphology, that is stromal collagenization which has led to the term ameloblastoma with pronounced desmoplasia hereby present a case of desmoplastic ameloblastoma in a 22 year female. Ameloblastoma is a benign odontogenic tumour of epithelial origin that exhibits a locally aggressive behaviour with a high level of recurrence. The desmoplastic ameloblastoma da is characterized by specific clinical, imaging, and. A case report on desmoplastic ameloblastoma of anterior mandible. By combining data from all eligible published reports, we have. A 40yearold man suffered from a repeatedly recurrent desmoplastic ameloblastoma in the right maxillary anterior and premolar regions. We report a case of desmoplastic ameloblastoma in a 45yearold female with a painless swelling in the left anterior maxillary region. Desmoplastic ameloblastoma is a rare variant of ameloblastoma and only 54 cases have been previously reported in the english literature. Our objective was to describe the clinical and pathological features of desmoplastic ameloblastoma.
It has been included in who classification of head and neck tumor who2005 as a variant of ameloblastoma. Ameloblastoma is a rare disorder of the jaw involving abnormal tissue growth. This type of lesion usually occurs in the maxillary anterior region. Apr 19, 2016 ameloblastoma is a rare, noncancerous benign tumor that typically develops in the jaw near the molars. Hybrid desmoplasticfollicular ameloblastoma of the. The surgical extirpation of ameloblastoma in mandible is challenging.
It differs from classical ameloblastoma in its site of occurrence, radiographic features, and histologic appearance. We retrospectively evaluated six da cases that were gathered from four different hospitals and confirmed histopathologically with resected specimens. Pdf a case report on desmoplastic ameloblastoma of anterior. The desmoplastic ameloblastoma is a variant of ameloblastoma characterized by specific clinical, radiological, and histological features. Peripheral desmoplastic ameloblastoma in adolescent age.
Ameloblastoma arising from a dentigerous cysta case report nvv satya bhushan1, naga malleswar rao2, m. Ameloblastoma genetic and rare diseases information center. Desmoplastic ameloblastoma da was first described in detail by eversole et al in 1984 and is defined as a variant of ameloblastoma with. Finally, the tumor histology became a small cystic and follicular pattern next to the desmoplastic type of ameloblastoma. However, in the desmoplastic type of this case, a histologically fibroosseous lesionlike pattern and hybrid pattern were not recognizable and radiologically, the relationship to the. Desmoplastic ameloblastoma is a rare variant of benign odontogenic tumors. Case of desmoplastic ameloblastoma arising in the anterior maxilla minako aiki 1, seigo ohba1,2, kyoko ishimaru 1, shinpei matsuda 1, hitoshi yoshimura1, shuichi fujita3, yoshiaki imamura4, kazuo sano1 1division of dentistry and oral surgery, department of sensory and locomotor medicine, faculty of medical sciences, university of fukui, japan.
Worldwide, maxillary ameloblastoma is rare, but its late detection renders adequate treatment difficult. A rare case report durga okade, tejavathi nagaraj, c. We report a case of desmoplastic ameloblastoma in a 45. This lesion occurs with the same frequency in the maxilla and mandible, although the predominant site is the anteriorpremolar site in. Odontogenic tumour, ameloblastoma, ameloblastoma unicystic, ameloblastoma solid, ameloblastoma multicystic. Reconstruction of palate with buccal fat pad secondary to.
They conclude that desmoplastic ameloblastoma may be less. Mar 16, 2016 desmoplastic ameloblastoma da is a rare variant that accounts for approximately 4 % of ameloblastoma, displaying significant differences in anatomical site, imaging, and histologic appearance. Ameloblastoma histopathology pdf ameloblastoma is a rare, benign or cancerous tumor of odontogenic epithelium much more commonly appearing in the lower. The third pattern is known as the desmoplastic ameloblastoma, which has dense bands of collagen and focal areas of calcification in which strands of preameloblasts with reverse polarity exist fig. Ameloblastoma is a rare, benign or cancerous tumor of odontogenic epithelium much more commonly appearing in the lower. Ameloblastoma can be either solid or multicystic, but they frequently demonstrate both characteristics. Desmoplastic ameloblastoma found in a dense collagen stroma that is hypocellular and hyalinized grow in thin strands and cords of epithelium epithelial proliferation seems to be compressed and fragmented by hyalinised stroma 24. It accounts for only 4% to % of all ameloblastomas. This is in contrast to classical type of ameloblastoma, which are found in the posterior region of mandible. Unicystic ameloblastoma in a 17 year old female case.
This type of odontogenic neoplasm was designated as an adamantinoma in 1885 by the french physician louischarles malassez. The location of this lesion, its histology and radiological features differ from those of conventional am. Ameloblastoma is a benign odontogenic tumor of epithelial origin. This study aimed to add to existing knowledge on 90 cases of desmoplastic ameloblastoma da previously. Desmoplastic ameloblastoma da was first described in detail by eversole et al. Although ameloblastomas are usually located in the mandible, this. The mean ages are 16 and 35 years for unerupted and erupted. In 1984 and in recent who classification of odontogenic tumors, it is defined as a variant of ameloblastoma with specific clinical, imaging.
Desmoplastic variant of ameloblastoma of the maxilla. Desmoplastic ameloblastoma da is a relatively rare histological variant of ameloblastoma with specific clinical, radiological, and histological features. Desmoplastic ameloblastoma differs from other variants of ameloblas toma in that it is more frequently seen in the anterior region of jaw and its mixed radiolucent. The age and gender groups affected by desmoplastic are similar to those affected by the conventional ameloblastoma. Ameloblastoma is the second most common odontogenic tumor ofepithelial origin 1. Desmoplastic ameloblastoma da is a rare variant of ameloblastoma am. Ameloblastoma is a rare, benign or cancerous tumor of odontogenic epithelium ameloblasts, or outside portion, of the teeth during development much more commonly appearing in the lower jaw than the upper jaw. Maxillary lesion are more insidious than mandibular tumors owing to. Reports of new cases of peripheral desmoplastic ameloblastoma are necessary for a better understanding of the origin and behavior of this particular subtype of ameloblastoma. Keerthi department of oral medicine and radiology, sri rajiv gandhi college of dental sciences, bengaluru, karnataka, india abstract desmoplastic ameloblastoma da is an uncommon variant of ameloblastoma that. The purpose of this study is to investigate ct and mr imaging findings of da. Among the variants of ameloblastoma, desmoplastic ameloblastoma is a rare and unique entity which is characterized by marked stromal desmoplasia. Hybrid lesions in which histopathologically conventional ameloblastoma coexists with areas of da are rare. Desmoplastic ameloblastoma da is one of the rare pathological variants of ameloblastoma.
The resulting tumors or cysts are usually not malignant benign but the tissue growth may be aggressive in the involved area. Desmoplastic ameloblastoma mimicking a periapical lesion. Desmoplastic ameloblastoma da is an uncommon variant of ameloblastoma that accounts for 4% of ameloblastomas. Several histologic types of ameloblastoma are described in the literature including plexiform, follicular, basal cell, granular cell, clear cell, and acanthomatous. Kiran kumar4 abstract we are reporting a case of an ameloblastoma which arose in the wall of a dentigerous cyst. Half of the desmoplastic ameloblastoma are located in the maxilla, and the vast majority occur in the anterior or premolar portion of jaws. Desomoplastic ameloblastoma da, a rare histologic variant of solid multicystic ameloblastoma sma was first reported in 1981 3. Among the ameloblastomas, the desmoplastic variation is rare. Follicular and plexiform are the main histopathological variants. We report a case of desmoplastic ameloblastoma in a 45yearold female with a painless swelling in the left anterior. The here presented retrospective analysis investigated the clinicoradiographic features of an overall of 115 dacases, having been reported in literature from 1984 to 2008.
Coincidently, the present case of desmoplastic ameloblastoma is also seen in a chinese woman from northeast of china. Up until now, less than 150 patients have been reported inthe literature. We report a case of desmoplastic ameloblastoma in a 45yearold female with a painless swelling in the leftanterior maxillary region. Ameloblastoma is a benign but locally aggressive odontogenic tumor. Majority occur in the mandible with about 520% occurring in the maxillary bone. In limited sample, may not be distinguishable from unicystic ameloblastoma macrocystic degeneration of conventional ameloblastoma limited biopsy sample requires inclusion of this entity in differential diagnosis basal palisading, with reverse polarity, hyperchromatic basal layer stellate reticulumlike layer. The purpose of this paper is to report a case of da mimicking a periapical lesion. A desmoplastic ameloblastoma is characterized by a large amount of collagen in its stroma, which is permeated by ovoidshaped islets, as well as strands of epithelial tumor cells of odontogenic origin. Ameloblastomas frequently occur in relatively young people, but are rarely seen in people aged 80 years or older. It was also proposed that the unique radiographic features of desmoplastic ameloblastoma, distinct from other histological typessubtypes, are a function of the desmoplasia. The peripheral desmoplastic ameloblastoma is a rare event, reported in only four cases involving adult patients. Dec 18, 2011 ameloblastoma, desmoplastic type, is a rare lesion for which radiographic images are even less common, and such lesions are sometimes considered to be variant types. It is locally aggressive with unlimited growth capacity and has a high potential for malignant transformation as well as metastasis.
It is the typical histopathological picture of the lesion exhibiting a blend of desmoplasia collagenization and ameloblastoma that leads to its. The world health organization 2005 classified this tumor as a variant of ameloblastoma. Desmoplastic ameloblastoma da is a newly recognised, rare odontogenic neoplasm that is a histological variant of ameloblastoma. A panoramic radiograph showed an area of radiolucency with.
The desmoplastic ameloblastoma da is characterized by specific clinical, imaging, and histological features. Desmoplastic ameloblastoma international journal of current. Maxillary ameloblastoma extending into the maxillary sinus. Hybrid desmoplasticfollicular ameloblastoma of the mandible. Hybrid desmoplastic ameloblastoma da composed of typical desmoplastic ameloblastoma along with areas of follicularplexiform ameloblastoma is an extremely rare variant of ameloblastoma. Desmoplastic ameloblastoma da is a rare variant of ameloblastoma, with specific clinical, imaginological and histopathological features. Arising from the odontogenic epithelium, ameloblastoma is the most commonly occurring benign aggressive tumor of the jaw. Pdf desmoplastic ameloblastomaan unusual presentation. Superiorly it is extends from line joining the angle of mouth to tragus to 1cm above. Except for the unicystic type, which has a low recurrence rate, no significant differences in the behaviour of these variants have been observed. During the first visit, the patient was provisionally histopathologically diagnosed with a developmental cyst, and it was confirmed to be unicystic ameloblastoma and resected. Apr 30, 2015 ameloblastoma is a rare odontogenic neoplasm of the mandible and maxilla, with multiple histologic variants, and high recurrence rates if improperly treated. Mar 18, 2011 desmoplastic ameloblastoma is a rare variant of ameloblastoma.
Pdf a repeatedly recurrent desmoplastic ameloblastoma. Unicystic ameloblastoma with diverse mural proliferation a hybrid. Up until now, less than 150 patients have been reported in the literature. Recurrent desmoplastic ameloblastoma of the maxilla. It originates in the cells that form the enamel that protects your teeth. Desmoplastic ameloblastoma is one of the six histopathological subtypes of ameloblastoma. A case report of desmoplastic ameloblastoma marcio bruno amaral 1,3, belini freiremaia 1, marcella rezende serpa 2, ricardo alves mesquita 4 1 professor department of oral and maxillofacial surgery, baleia hospitalcentrare, belo horizonte, mg, brazil.
Pdf desmoplastic ameloblastoma da is a rare variant that accounts for approximately 4 % of ameloblastoma, displaying significant. The surgical reconstruction outcome has been satisfactory up to 12 months post surgery. Desmoplastic ameloblastoma of mandible bmj case reports. Unicystic ameloblastoma is an infrequent variant and accounts for 5 15% of all ameloblastomas 2. The current mainstay of treatment is wide local excision with appropriate margins and immediate reconstruction. A 40yearold male was referred to our hospital complaining of a swelling in the right premolar region of the mandible. We report ten cases of desmoplastic ameloblastoma of the jaw observed between 1972 and 1998 and. Furthermore, the airway adequacy is crucial, both during and after mandibulectomy. Ameloblastoma symptoms, histology, radiology and diagnosis, surgery, treatment. The patient was a 82yearold man who noticed swelling of the gingiva approximately 2 weeks prior to his initial visit. Molecular etiopathogenesis of ameloblastoma current. Greater tendency to grow in thin strands and cords of epithelium rather than in an island like pattern. The patient visited our hospital with a chief complaint of swelling around the upper left premolars.